The present study was aimed at developing and exploring the use of long circulating biocompatible PEGylated PPI 5.0G dendrimers for delivery of an anti-cancer drug, Imatinib. The PPI 5.0G dendrimers were synthesized and PEGylated using dicyclohexyl carbodimide (DCC). PEGylation was confirmed by IR, NMR. The Imatinib was loaded in PEGylated dendritic system and pH dependent in-vitro drug release was determined. The in-vitro release studies demonstrated suitability of PEGylated PPI 5.0G dendrimer for prolonged delivery of Imatinib. PEGylation is considered to be suitable for amendment of PPI dendrimers for improving drug-loading capacity and stabilizes the system in body. The results suggested that, such PEGylated dendrimeric system is suitable for sustained delivery of imatinib.
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